Gene information
Official symbol GSTP1
Official full name glutathione S-transferase pi 1
Gene type protein-coding gene
Chromosome11q13.2
Alias symbolGSTP
Previous symbolFAEES3; GST3
Gene familySoluble glutathione S-transferases
Resources
Entrez Gene 2950
HGNC HGNC:4638
Ensembl ENSG00000084207
Vega OTTHUMG00000137430
UCSC uc001omf.4
GO terms: 109 records
GO Description Category LogP Number of genes Detail
GO:0000302 response to reactive oxygen species GO Biological Processes -13.4775134 34 More
GO:0001676 long-chain fatty acid metabolic process GO Biological Processes -13.6883394 17 More
GO:0001818 negative regulation of cytokine production GO Biological Processes -48.9957481 97 More
GO:0001933 negative regulation of protein phosphorylation GO Biological Processes -19.8214973 59 More
GO:0001959 regulation of cytokine-mediated signaling pathway GO Biological Processes -13.0991884 33 More
GO:0001960 negative regulation of cytokine-mediated signaling pathway GO Biological Processes -11.0318814 22 More
GO:0002237 response to molecule of bacterial origin GO Biological Processes -48.4964960 93 More
GO:0002673 regulation of acute inflammatory response GO Biological Processes -15.6954767 14 More
GO:0004364 glutathione transferase activity GO Molecular Functions -3.62663932 4 More
GO:0004601 peroxidase activity GO Molecular Functions -5.52369866 7 More
GO:0004602 glutathione peroxidase activity GO Molecular Functions -2.66707306 3 More
GO:0005504 fatty acid binding GO Molecular Functions -3.74766542 9 More
GO:0006469 negative regulation of protein kinase activity GO Biological Processes -12.6852914 37 More
GO:0006518 peptide metabolic process GO Biological Processes -2.74792434 15 More
GO:0006575 cellular modified amino acid metabolic process GO Biological Processes -7.43961662 26 More
GO:0006631 fatty acid metabolic process GO Biological Processes -20.3287405 33 More
GO:0006633 fatty acid biosynthetic process GO Biological Processes -12.0711739 16 More
GO:0006690 icosanoid metabolic process GO Biological Processes -21.0788451 23 More
GO:0006692 prostanoid metabolic process GO Biological Processes -9.18831190 9 More
GO:0006693 prostaglandin metabolic process GO Biological Processes -9.18831190 9 More
GO:0006749 glutathione metabolic process GO Biological Processes -3.95134537 6 More
GO:0006790 sulfur compound metabolic process GO Biological Processes -3.12963557 12 More
GO:0006805 xenobiotic metabolic process GO Biological Processes -8.19045514 12 More
GO:0006979 response to oxidative stress GO Biological Processes -17.6147653 58 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0008610 lipid biosynthetic process GO Biological Processes -6.38047816 23 More
GO:0009410 response to xenobiotic stimulus GO Biological Processes -32.6021211 82 More
GO:0009636 response to toxic substance GO Biological Processes -18.1818984 46 More
GO:0010563 negative regulation of phosphorus metabolic process GO Biological Processes -21.7837721 71 More
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway GO Biological Processes -3.24021630 5 More
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway GO Biological Processes -2.36203981 3 More
GO:0016053 organic acid biosynthetic process GO Biological Processes -15.6178787 26 More
GO:0016209 antioxidant activity GO Molecular Functions -11.3593886 22 More
GO:0016491 oxidoreductase activity GO Molecular Functions -14.1519969 39 More
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor GO Molecular Functions -5.30702712 7 More
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GO Molecular Functions -2.27622518 4 More
GO:0019900 kinase binding GO Molecular Functions -6.03057706 62 More
GO:0019901 protein kinase binding GO Molecular Functions -6.66055444 59 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031348 negative regulation of defense response GO Biological Processes -30.3795513 65 More
GO:0031400 negative regulation of protein modification process GO Biological Processes -17.0986645 70 More
GO:0031406 carboxylic acid binding GO Molecular Functions -5.96500660 23 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032496 response to lipopolysaccharide GO Biological Processes -45.257773 87 More
GO:0032642 regulation of chemokine production GO Biological Processes -25.2850711 37 More
GO:0032651 regulation of interleukin-1 beta production GO Biological Processes -19.7300517 34 More
GO:0032652 regulation of interleukin-1 production GO Biological Processes -24.2088254 41 More
GO:0032680 regulation of tumor necrosis factor production GO Biological Processes -32.0729913 56 More
GO:0032682 negative regulation of chemokine production GO Biological Processes -6.18749803 9 More
GO:0032691 negative regulation of interleukin-1 beta production GO Biological Processes -9.98402343 15 More
GO:0032692 negative regulation of interleukin-1 production GO Biological Processes -11.9554195 18 More
GO:0032720 negative regulation of tumor necrosis factor production GO Biological Processes -18.6356508 28 More
GO:0032787 monocarboxylic acid metabolic process GO Biological Processes -19.1871601 38 More
GO:0032873 negative regulation of stress-activated MAPK cascade GO Biological Processes -3.60984508 9 More
GO:0032928 regulation of superoxide anion generation GO Biological Processes -6.91942497 9 More
GO:0032930 positive regulation of superoxide anion generation GO Biological Processes -6.32323278 8 More
GO:0033293 monocarboxylic acid binding GO Molecular Functions -4.50166323 13 More
GO:0033483 gas homeostasis GO Biological Processes -3.72958795 3 More
GO:0033559 unsaturated fatty acid metabolic process GO Biological Processes -16.8056258 19 More
GO:0033673 negative regulation of kinase activity GO Biological Processes -12.5521161 39 More
GO:0042326 negative regulation of phosphorylation GO Biological Processes -20.6187298 64 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO Biological Processes -8.71585030 18 More
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling GO Biological Processes -3.60984508 9 More
GO:0043405 regulation of MAP kinase activity GO Biological Processes -18.9267681 42 More
GO:0043407 negative regulation of MAP kinase activity GO Biological Processes -8.66647370 10 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043409 negative regulation of MAPK cascade GO Biological Processes -13.5471736 35 More
GO:0043506 regulation of JUN kinase activity GO Biological Processes -3.13739094 5 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0043603 cellular amide metabolic process GO Biological Processes -1.84597279 17 More
GO:0044272 sulfur compound biosynthetic process GO Biological Processes -2.83849636 7 More
GO:0044283 small molecule biosynthetic process GO Biological Processes -16.6163676 33 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045936 negative regulation of phosphate metabolic process GO Biological Processes -21.8424865 71 More
GO:0046328 regulation of JNK cascade GO Biological Processes -6.26985667 21 More
GO:0046329 negative regulation of JNK cascade GO Biological Processes -2.96833359 7 More
GO:0046394 carboxylic acid biosynthetic process GO Biological Processes -15.6974044 26 More
GO:0048145 regulation of fibroblast proliferation GO Biological Processes -11.1167439 21 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050728 negative regulation of inflammatory response GO Biological Processes -31.0556128 55 More
GO:0051348 negative regulation of transferase activity GO Biological Processes -13.2006110 43 More
GO:0060759 regulation of response to cytokine stimulus GO Biological Processes -13.7003447 35 More
GO:0060761 negative regulation of response to cytokine stimulus GO Biological Processes -10.5179624 22 More
GO:0070303 negative regulation of stress-activated protein kinase signaling cascade GO Biological Processes -3.60984508 9 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070664 negative regulation of leukocyte proliferation GO Biological Processes -3.96184640 13 More
GO:0071216 cellular response to biotic stimulus GO Biological Processes -28.1549742 59 More
GO:0071219 cellular response to molecule of bacterial origin GO Biological Processes -28.3848077 56 More
GO:0071222 cellular response to lipopolysaccharide GO Biological Processes -26.0381191 52 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071466 cellular response to xenobiotic stimulus GO Biological Processes -9.33788411 28 More
GO:0071637 regulation of monocyte chemotactic protein-1 production GO Biological Processes -4.00389964 4 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0071901 negative regulation of protein serine/threonine kinase activity GO Biological Processes -13.7044922 29 More
GO:0072330 monocarboxylic acid biosynthetic process GO Biological Processes -12.0346130 18 More
GO:0080135 regulation of cellular response to stress GO Biological Processes -19.0128542 89 More
GO:0090322 regulation of superoxide metabolic process GO Biological Processes -9.31154255 13 More
GO:0097237 cellular response to toxic substance GO Biological Processes -13.7473733 28 More
GO:0098754 detoxification GO Biological Processes -12.4136065 17 More
GO:0098869 cellular oxidant detoxification GO Biological Processes -12.6410846 24 More
GO:0120254 olefinic compound metabolic process GO Biological Processes -12.8805599 18 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -32.3948799 57 More
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production GO Biological Processes -18.2876323 28 More
GO:1990748 cellular detoxification GO Biological Processes -12.8821364 16 More
GO:2000377 regulation of reactive oxygen species metabolic process GO Biological Processes -19.1025541 38 More
KEGG pathways: 8 records
KEGG Description Category LogP Number of genes Detail
hsa00480 Glutathione metabolism KEGG Pathway -3.20525659 5 More
hsa00980 Metabolism of xenobiotics by cytochrome P450 KEGG Pathway -5.38623088 8 More
hsa00982 Drug metabolism - cytochrome P450 KEGG Pathway -7.86918833 10 More
hsa00983 Drug metabolism - other enzymes KEGG Pathway -2.57730801 5 More
hsa01524 Platinum drug resistance KEGG Pathway -2.75238159 5 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05204 Chemical carcinogenesis - DNA adducts KEGG Pathway -6.89688307 9 More
hsa05225 Hepatocellular carcinoma KEGG Pathway -5.07719186 21 More
Drug-Gene interaction
view
Related drugs: 48 records
Drug name Interaction type Source PMID View
adriamycin NCI 2897875 view
alcohol NCI 1302037 view
azacitidine NCI 11696442 view
bleomycin PharmGKB view
busulfan NCIPharmGKB 15779864 view
camptothecin NCI 15500952 view
canfosfamide TdgClinicalTrialTTD 1601411112738715 view
carboplatin NCICIViC 2501086412360105 view
cisplatin NCICIViCPharmGKB 1978698025010864110627462218836117409936152547633166671425592234 view
curcumin NCI 159991039463521 view
cyclophosphamide NCIPharmGKB 19786980250088672136236522188361205680499382956 view
cytarabine NCI 3978635 view
daunorubicin PharmGKB 25119182 view
decitabine NCI 1194811811960994 view
dexamethasone NCI 1302037 view
ditiocarb NCI 2992773 view
docetaxel NCI 10639573 view
doxorubicin PharmGKB 11351295 view
droloxifene NCI 11721384 view
epirubicin PharmGKB 250088672136236520568049 view
etoposide PharmGKB 12969965 view
exatecan mesylate NCI 10639573 view
ezatiostat TdgClinicalTrialTTD 10592235 view
ezatiostat hydrochloride inhibitor ChemblInteractions view
fluorouracil PharmGKB 279959892144968118540691 view
garlic NCI 11962257 view
hydroquinone NCI 15141365 view
ifosfamide NCI 16282887 view
irinotecan hydrochloride NCI 10639573 view
isoniazid PharmGKB 257985822903617627281183 view
leucovorin PharmGKB view
lycopene NCI 10806309 view
melphalan NCI 157798641988111 view
misonidazole NCI 3753520 view
omeprazole NCI 8529327 view
oxaliplatin NCIPharmGKB 1072858722188361174099361207254794982762799598917401013192037831509327312435115113071471175144020530282167076012144968115213713 view
paclitaxel CIViC 25010864 view
perfosfamide NCI 9382956 view
platinum PharmGKB 27462924 view
prednisone NCI 11186134 view
pyrimethamine PharmGKB 11807801 view
resveratrol NCI 11279601 view
rifampin PharmGKB 257985822903617627281183 view
selenomethionine NCI 1759407 view
sulforaphane NCI 1549603 view
thiotepa PharmGKB view
verapamil NCI 3566185 view
vitamin e NCI 17029404 view
Related studies: 2 records
Molecular factor Omics type Application Objective MI type Reference
NM_000852.4:c.313A>G genomics acute myocardial infarction[diagnosis] acute myocardial infarction Singh N et al. Cardiology. 2011
NM_000852.4:c.[313A>G;341C>T] genomics acute myocardial infarction[diagnosis] acute myocardial infarction Kovacs V et al. Mol Cell Biochem. 2014
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